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KMID : 0391520150230030143
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Journal of the Korean Child Neurology Society
2015 Volume.23 No. 3 p.143 ~ p.147
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A Case of Mild Influenza-Associated Encephalopathy with Biphasic Seizures and Late Reduced Diffusion in Korea
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Pyo Jin-Kyu
Yun Hye-Won
Yu Hee-Joon
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Abstract
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Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD)
is one form of encephalopathy that has a biphasic clinical course and a typical
magnetic resonance imaging (MRI) finding of reduced diffusion in the frontal or
frontoparietal subcortical white matter, with sparing of the perirolandic region.
There have been no previous reports of influenza-associated AESD in Korea, while
approximately 20 cases per annum have been reported in Japan. We report a 24-
month-old Korean female with a clinically, radiologically diagnosed mild form of
AESD associated with influenza A. The patient had a complex partial seizure on the
second day of fever, followed by a cluster of brief seizures on the fifth day of viral
febrile disease. MRI showed diffusion restrictions on the subcortical white matter
and cortex of both frontoparietal lobes. Influenza A was proven after her temperature
had fallen. Her clinical symptoms improved gradually without using oseltamivir,
and no other neurologic sequelae remained. This case report is the first reported
mild form of influenza-associated AESD in Korea. The ethnicity and regionality of
influenza-associated encephalopathy should be widely studied.
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KEYWORD
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Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD), Encephalopathy, Influenza
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